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CBD Oil Dosage: How Much Should You Take? Recommendations for various diseases

By and large, there is the acceptance and use of Cannabidiol as a therapeutic, healing substance still in its infancy.

Healthcare professionals and scientists are only now beginning to develop dosage schedules for medical marijuana, medicinal hemp and its extracts (including CBD oil).

Even with the current legalization of medical marijuana as in the US and other countries, many doctors are reluctant to Cannabinoids how to prescribe CBD. There are two reasons for this:

  1. Doctors cannot (only recommend) prescribing cannabinoids because there is no Recommended Daily Allowance (RDA) or universal dose for all people.
  2. Most medical schools never cover CBD / cannabidiol therapy in their pharmacology courses (the drug curriculum revolves mostly around patentable substances).

there is no recommended dosage of CBD oil information on this page is provided as an information guide - as a starting point - and should never be viewed as medical advice.

Table of Contents

Every person is different

There are countless variables such as weight, diet, metabolism, genetics, environment, product consistency and more that make a generally prescribed dosage of CBD oil impossible.

While we wish there were a mathematical CBD dosage calculator, it's not that simple - very rough estimates are what we have to be content with.

With these facts in mind, most people who first use CBD oil for pain or other ailments start by using the minimum recommended dosage then gradually increasing the dose until you get the results you want.

A general Recommended intake for CBD oil is 25 mg, twice daily.

Additionally, the amount of CBD should be increased by 25 mg every 3-4 weeks until you achieve symptom relief (conversely, decrease by 25 mg if symptoms worsen).

Additionally, it can be useful to write down your daily experiences in a notebook so that you can narrow down exactly what works best for you and feels best.

With that understanding, now is the time to learn more about CBD oil and find the right CBD oil dosage for you and your symptoms.

How Much CBD Oil Should I Take?

The Mayo Clinic suggests CBD dosages based on scientific research, publications, traditional use, and expert opinion.

The Dosage of cannabinoids and the length of treatment depends mainly on the disease (and myriad other factors).

The following table from the Mayo Clinic provides specific Dosage recommendations for various diseases:

  • Loss of appetite in cancer patients: 2.5 mg THC (oral), with or without 1 mg CBD for six weeks (1)
  • Chronic pain: 2.5-20 mg CBD (with or without THC) (oral) (2)
  • Epilepsy: 200-300mg CBD (oral) daily (3)
  • Movement problems due to Huntington's disease: 10 mg CBD per kg body weight daily for six weeks (oral) (4)
  • Sleep disorders: 40mg-160mg CBD (oral) (5)
  • Multiple Sclerosis (MS) Symptoms: Cannabis plant extracts with 2.5-120 milligrams of a THC / CBD combination daily for 2-15 weeks. Patients typically use eight sprays within three hours, with a maximum of 48 sprays within 24 hours (6)
  • Schizophrenia: 40-1,280 mg oral CBD daily (7) (
  • Glaucoma: A single sublingual CBD dose of 20-40 mg (> 40 mg can increase eye pressure) (8)

Different types of CBD products

CBD hemp oil comes in seemingly endless forms, each with a different concentration of CBD and other phytocannabinoids.

Determining the use of CBD oil begins with your route of administration - in other words, choosing the best way to take CBD oil for your needs and lifestyle.

This includes…

Oral intake by mouth

  • Liquid hemp oil, such as CBD tinctures or CBD drops
  • CBD concentrated in a thick paste (often referred to as Rick Simpson Oil or RSO)
  • CBD oil in capsule form
  • Phytocannabinoid-rich sprays / pipette bottle (generally designed for use under the tongue)
  • Bottled water with nano-sized CBD particles
  • CBD infused chewing gum
  • Soluble powders containing CBD (often mixed with other adaptogenic herbs)
  • Edible oils (e.g. coconut oil or olive oil) with the addition of cannabinoids
  • CBD-infused foods (i.e. chewing gums, brownies, cookies, etc. (generally for those who are sensitive to smoking)

Ingestion via inhalation / smoking

  • Crystalline isolates
  • Wax (similar to THC-containing marijuana concentrates, called "shatter")
  • CBD-rich e-liquids and / or vape cartridges (similar to an e-cigarette)

External use on the skin

  • Transdermal patches with CBD (similar to a nicotine patch)
  • Cannabidiol-infused ointments, balms, lotions, shampoos, or soaps (for topical use)
  • Bath bombs with CBD infusions

What is the best intake of CBD oil?

While many options like chewing gum don't require guidance, we've rounded up these tips for taking CBD oil:

Liquid CBD oil: Drops or tinctures should have a "recommended serving size" and indicate the total amount of milligrams of CBD on their packaging. From there, you can determine the amount of CBD that you want to take. Simply place the right amount of drops under your tongue with the pipette and leave the CBD oil there for at least 60 seconds without swallowing. The dwell time of 60 seconds enables absorption via the blood vessels under the tongue - and thus efficiently bypasses the first-pass metabolism. After 60 seconds, swallow the CBD oil.

CBD e-liquid / vape cartridges: Vaping is great for people looking for an instant response as inhalation is the fastest way to deliver CBDs to the brain. To use vape, just gently exhale the air from your lungs, then inhale slowly through the mouthpiece of the CBD vaporizer for 3 seconds. Then fill your lungs with extra air and hold it for a few seconds, then slowly exhale again. There are pre-filled, inexpensive vape pens and cartridges, as well as more expensive vaporizers that you can refill with CBD-infused e-liquids.

CBD foods: For ingesting foods containing CBD, the only steps necessary are: open, eat, and enjoy! This type of consumption will result in longer-lasting effects that will also take a little longer to take effect than some of the other options. Food is great for those looking to make a lasting impact or for those who want to be more discreet about their use of CBDs.

CBD isolates / concentrates: Anyone familiar with smoking hash or other cannabis concentrates like wax and BHO will be no stranger to this dosage form. Simply sprinkle into a vaporizer or water pipe, ignite, inhale and enjoy. We find this CBD option useful for individuals looking to increase their regular consumption of CBD-rich cannabis flowers or other smokable herbs.

Choose a brand of CBD that you can trust

Figuring out how much CBD oil to ingest can feel like trying to navigate a complicated maze.

The sheer volume of CBD manufacturers in the market can create confusion for consumers, and if you look closer, it's not difficult to see why. The providers not only use different starting materials (CBD-rich cannabis vs. industrial hemp, different varieties, etc.), but also use different extraction techniques.

In addition to the confusion, many providers recommend excessive dosages while others suggest amounts that are a fraction of what experts believe is effective.

As with a fermented food like kombucha, slight natural fluctuations are normal and to be expected in a product like CBD oil because it is made from live plants. Changes in weather, soil and water can affect the biology of the feedstock.

Even the most reputable five-star companies have no way of controlling every variable in this organic process.

When buying CBD oil, you should always choose a reputable manufacturer who gives reliable dosage recommendations on its products and has good reviews and customer recommendations.

The health benefits of CBD oil

Cannabinoids like CBD have numerous beneficial effects in the human body, from reducing inflammation to improving anxiety and depression.

You don't have to have a serious illness to benefit from CBD oil. Even healthy people can experience a remarkable increase in their quality of life by taking CBD Oil 5%, CBD Oil 10% or CBD Oil 20%.

Below is an overview of diseases and conditions whose symptoms can be relieved by CBD oil:

  • Pain (neuropathic, chronic etc.)
  • epilepsy
  • Multiple sclerosis (MS)
  • Amyotrophic lateral sclerosis (ALS)
  • Parkinson's
  • Inflammation
  • acne
  • Dyskinesia
  • psoriasis
  • Broken bones
  • depressions
  • Bacterial infections
  • diabetes
  • Rheumatoid arthritis
  • nausea
  • Anxiety
  • ADHD
  • schizophrenia
  • Addiction / withdrawal
  • Heart disease
  • Irritable bowel syndrome (IBS)

Please note that this list of CBD health benefits is by no means exhaustive. Science is only just beginning to understand how the use of cannabinoids can help improve numerous ailments in a variety of ways.

Is it possible to overdose on CBD?

There is no known dose of CBD that can be fatal. Chronic ingestion of high doses of up to 1500 mg per day has repeatedly proven to be well tolerated.

As with any natural product, it is important to speak to your doctor before beginning use. There are some slight risks and side effects associated with using CBD in high doses or for an extended period of time, including:

  • Low blood pressure
  • Dry mouth
  • Drowsiness
  • Sedation
  • Reduced T and B cell activity
  • Decreased fertility
  • Reduced p-glycoprotein activity
  • Reduced activity of cytochrome P450 (CYP450) enzymes

These side effects are worst-case scenarios if you take too much CBD and are not necessarily typical.

There is one major exception to the "generally harmless" attitude towards CBD, namely the negative effects cannabinoids can have on the function of the liver enzyme CYP450. About 60% of all pharmaceutical drugs go through metabolism through this enzyme, including:

  • Steroids
  • HMG CoA reductase inhibitor for reductases
  • Calcium channel blockers
  • Antihistamines
  • Prokinetics
  • HIV antivirals
  • Immunomodulators
  • Benzodiazepines
  • Antiarrhythmics
  • Antibiotics
  • Anesthetic
  • Antipsychotics
  • Antidepressants
  • Anti-epileptics
  • Beta blockers
  • PPIs
  • NSAIDs
  • Angiotensin II blockers
  • Oral hypoglycemic agents
  • Sulfonylureas

It's important to note that even something as benign as grapefruit juice can have the same enzyme-inhibiting effects on CYP450 as CBD.

The most important things to do before taking CBD (or any other herbal product) are researching possible drug interactions and speaking with your doctor to clarify additional questions about CBD drug interactions or overdose issues.

How genetics affect CBD dosage

As if there weren't enough factors to consider when deciding your ideal CBD oil dosage, your own genetics can also influence this amount.

Some individuals have mutations in the CNR1 gene, which is responsible for coding the CB1 receptor (a type of receptor in cells throughout the body that interacts with cannabinoids).

Problems with the CNR1 gene can ultimately lead to a malfunctioning endocannabinoid system, which is an important variable in determining which CBD oil to use.

Here are some other cell-level factors that can affect how CBD is absorbed in your body:

Various substances can severely affect the CB1 receptors. Certain lifestyle choices can affect how your body converts CBD.

  • What does that mean? Well, for example, THC increases the activity of the CB1 receptors, while ethanol (alcohol) increases its expression. In theory, smoking cannabis and consuming alcohol can increase the effects of CBD (9, 10).

Morphine and adrenaline decrease the activity of the CB1 receptor (11, 12).

  • What does that mean? It may mean that those currently using opiates, with their doctor's approval and guidance, might find CBD useful in reducing opiate use.

Exercise and nicotine both increase levels of anandamide (similar to THC - this is a cannabinoid that we naturally synthesize in our brain), which is a natural CB1 receptor activator (13).

  • What does that mean? Being physically active and consuming nicotine (although the latter is not recommended) can increase the effects of CBD.

DHA (an omega-3 fatty acid) increases CB1 receptors (14).

  • What does that mean? In theory, of course, those on a high-fat diet would need to use less CBD oil.

Prolonged elevated glucocorticoids (like cortisol) reduce the CB1 receptor density (15).

  • What does that mean? Those who are under high chronic stress would potentially need to take a higher dose of CBD oil to get the same effects as people who are not chronically stressed.

We're just beginning to understand genetics. As with any natural product, you should consult with your doctor about any questions and / or concerns about CBD and the use of CBD oil.

CBD oil is not addictive

People often ask us, "Can I get addicted to CBD oil?"

This is a tricky question, and the answer ultimately depends on the way you think.

Based on chemistry, the answer is no. Cannabidiol is not physically addictive in the same way that substances like heroin, cocaine, alcohol, opiates, benzodiazepines, and related substances can be. In addition, once used, CBD cannot cause physical withdrawal symptoms per se.

Interestingly, CBD is currently being studied for its ability to minimize withdrawal from drugs with severe withdrawal symptoms, such as opiates.

However, people can become addicted to almost anything that is not chemically addictive: exercise, music, sex, and food are good examples.

Those who take CBD daily to relieve symptoms of chronic illness and other serious illnesses may find that their uncomfortable sensations return shortly after skipping a dose.

This is no different than when the headache returns as soon as the effects of ibuprofen wear off.

However, because CBD can alter levels of liver essential enzymes, it is crucial to do your own research, speak to your doctor, and find the best way to use CBD oil for your specific situation.

Information and your own research will be your allies on your way to healing.


CBD oil has been studied for its potential role in treating many common health problems, including pain, anxiety, depression, acne, and heart disease.

For people with cancer, it can even be a natural alternative to pain and symptom management.

Research into the effects and health benefits of CBD oil is ongoing, so additional and new therapeutic uses for this natural remedy are sure to be discovered soon.

While there is much to be learned about the effectiveness and safety of CBD oil, the results of recent studies suggest that CBD and cannabis oils can offer safe and effective natural treatment for many health problems.

CBD oil can be bought without a prescription and many products are available on Amazon.

Personally, I take this CBD oil 10% from BioCBD every day. It is a top quality cannabis and hemp oil.

Many products are imported from other regions such as Asia and the USA. BioCBD's products are made in Europe and are subject to the highest standards in the world.A premium CBD oil that is still filled into glass by hand, free of artificial additives.

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