What is Hoellen Engel Dago 2008
Multiple orphan histidine kinases interact directly with Spo0A to control the initiation of endospore formation in Clostridium acetobutylicum
The phosphorylated Spo0A transcription factor controls the initiation of endospore formation in Clostridium acetobutylicum, but genes encoding key phosphorelay components, Spo0F and Spo0B, are… Expand
Binding of transcriptional activators to sigma 54 in the presence of the transition state analogue ADP-aluminum fluoride: insights into activator mechanochemical action.
Conformational changes in sigma 54 (sigma (54)) and sigma (54) -holoenzyme depend on nucleotide hydrolysis by an activator. We now show that sigma (54) and its holoenzyme bind to the central… Expand
Structural basis of histidine kinase autophosphorylation deduced by integrating genomics, molecular dynamics, and mutagenesis
Signal transduction proteins such as bacterial sensor histidine kinases, designed to transition between multiple conformations, are often ruled by unstable transient interactions making structural… Expand
Rapid Phenotypic and Genomic Change in Response to Therapeutic Pressure in Prostate Cancer Inferred by High Content Analysis of Single Circulating Tumor Cells
Timely characterization of a cancer's evolution is required to predict treatment efficacy and to detect resistance early. High content analysis of single Circulating Tumor Cells (CTCs) enables… Expand
A Role for the Conserved GAFTGA Motif of AAA + Transcription Activators in Sensing Promoter DNA Conformation *
Transcription from σ54-dependent bacterial promoters can be regarded as a second paradigm for bacterial gene transcription. The initial σ54-RNA polymerase (RNAP) promoter complex, the closed complex,… Expand
Chromosomal Instability Estimation Based on Next Generation Sequencing and Single Cell Genome Wide Copy Number Variation Analysis
Genomic instability is a hallmark of cancer often associated with poor patient outcome and resistance to targeted therapy. Assessment of genomic instability in bulk tumor or biopsy can be complicated ... Expand
Morphology-Predicted Large-Scale Transition Number in Circulating Tumor Cells Identifies a Chromosomal Instability Biomarker Associated with Poor Outcome in Castration-Resistant Prostate Cancer
A rapidly assessable biomarker of chromosomal instability in CTC is associated with poor outcomes when detected in men with progressing mCRPC. Chromosomal instability (CIN) increases a tumor cell's… Expand
Communication between Eσ54, promoter DNA and the conserved threonine residue in the GAFTGA motif of the PspF σ54 ‐ dependent activator during transcription activation
Conversion of Eσ54 closed promoter complexes to open promoter complexes requires specialized activators which are members of the AAA (ATPases Associated with various cellular activities) protein… Expand
Phenotypic and genomic characterization of CTCs as a biomarker for prediction of Veliparib therapy benefit in mCRPC.
5012Background: Response to PARPi in mCRPC patients (pts) particularly those with DNA damage response mutations (DDRm) was observed in the TOPARP trials (utilizing Olaparib) which enrolled heavily ...
A single cell genomic signature to detect homologous recombination deficiency (HRD) and PARP inhibitors sensitivity using patient's circulating tumor cells (CTCs).
e23015Background: PARPi have been successfully exploited as therapeutic agents in breast and ovarian tumors with HRD associated with germline BRCA mutations, and recently in metastatic castration r ...
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